One Pomegranate a Day in Just 10ml!
By harnessing the power of bioactive compounds like punicalagins, curcumin, and essential micronutrients, MILESTONE® “Gene-Smart” Pomegranate Concentrate is designed to activate key biological pathways influenced by your genetic makeup.
Targeted Nutrition for Cellular Health
| Key Benefits | Bioactive Compound | Gene Target | Biological Function |
|---|---|---|---|
Anti-inflammatory, immune support, antioxidant protection.
|
Curcumin | NF-κB | Reduces inflammatory signaling, inhibits pro-inflammatory pathways 1. |
| Punicalagins | Nrf2 | Enhances antioxidant response, combats oxidative stress 2. | |
| Vitamin D3 | VDR | Regulates immune function, improves calcium metabolism 3). |
Targeted Nutrition for Cellular Health
| Key Benefits | Bioactive Compound | Gene Target | Biological Function |
|---|---|---|---|
Bone strength, gut microbiome support, metabolic health.
|
Ellagic Acid | NRF2 | Activates antioxidant pathways, reducing oxidative stress 4. |
| Fermented Polyphenols | FUT2 | Enhances gut microbiome diversity, promoting digestive health 5. | |
| Calcium & Potassium | TRPV6, ATP2B1 | Supports bone density, regulates calcium absorption 6. |
Targeted Nutrition for Cellular Health
| Key Benefits | Bioactive Compound | Gene Target | Biological Function |
|---|---|---|---|
Energy production, red blood cell formation, cognitive support.
|
Vitamin B12 (Methylcobalamin) | MTR, MTRR | Supports red blood cell production, enhances cognitive function 7. |
| Iron (Ferrous Bisglycinate) | TFR1 | Boosts iron absorption, prevents anemia 8. | |
| Punicalagins | Nrf2 | Enhances antioxidant activity, supports vascular health 9. |
Each MILESTONE® High Phenolic Olive Oil is scientifically formulated to activate key biological pathways influenced by your genetic makeup. By leveraging targeted bioactives, we bridge the gap between your DNA and nutrition—delivering precision solutions to support heart health, brain function, inflammation balance, and metabolic well-being.
Modulating Genes Through Food
| Key Benefits | Bioactive Compound | Gene Target | Biological Function |
|---|---|---|---|
Cardiovascular health, brain function, inflammation modulation.
|
Oleocanthal | IL-6, TNF-α | Reduces inflammation by inhibiting pro-inflammatory cytokines 10. |
| Hydroxytyrosol | SOD2, GPX1 | Enhances antioxidant defenses, protecting against oxidative stress 11. | |
| DHA & EPA (Algae Omega-3s) | APOA5, FADS1 | Regulates lipid metabolism, supporting heart and brain health 12. | |
| ALA (Alpha-Linolenic Acid) | PPAR-γ | Modulates gene expression involved in lipid metabolism and inflammation 13. |
Modulating Genes Through Food
| Key Benefits | Bioactive Compound | Gene Target | Biological Function |
|---|---|---|---|
Immune function, bone health, inflammation control.
|
Vitamin D3 (Cholecalciferol) | VDR | Regulates calcium absorption and modulates immune response 14. |
| Oleocanthal | IL-6, TNF-α | Inhibits pro-inflammatory pathways, reducing inflammation 15. | |
| Hydroxytyrosol | SOD2, GPX1 | Provides antioxidant protection, supporting cellular health 16. |
Modulating Genes Through Food
| Key Benefits | Bioactive Compound | Gene Target | Biological Function |
|---|---|---|---|
Cardiovascular support, anti-inflammatory effects, metabolic health.
|
Oleocanthal | IL-6, TNF-α | Suppresses inflammatory responses 17. |
| Hydroxytyrosol | SOD2, GPX1 | Enhances antioxidant enzyme activity 18. | |
| Oleuropein | NF-κB | Modulates immune response 19. |
- Gupta et al., 2013 - A comprehensive review on the anti-inflammatory properties of curcumin, highlighting its ability to modulate NF-κB activity and reduce chronic inflammation[↩]
- Lansky & Newman, 2007 - This study explores the role of pomegranate-derived punicalagins in activating Nrf2, a key regulator of cellular antioxidant defense systems[↩]
- Holick, 2011 - A seminal paper discussing the functions of vitamin D3 in regulating immune responses and calcium homeostasis through the vitamin D receptor (VDR[↩]
- Seeram et al., 2005 - This study examines the antioxidant properties of ellagic acid and its role in activating NRF2 pathways to combat oxidative stress[↩]
- Henning et al., 2017 - This research highlights how polyphenols influence FUT2 gene expression, improving gut microbiome diversity and overall digestive health[↩]
- Cashman, 2002 - A foundational study on calcium metabolism, emphasizing the role of TRPV6 and ATP2B1 in calcium absorption and bone health[↩]
- O’Leary & Samman, 2010 - This study highlights the role of vitamin B12 in DNA synthesis, red blood cell formation, and its critical impact on neurological function[↩]
- Abbaspour et al., 2014 - A comprehensive review on iron metabolism, detailing how the transferrin receptor 1 (TFR1) regulates iron uptake and prevents anemia[↩]
- Lansky & Newman, 2007 - This research explores the cardiovascular benefits of punicalagins, showing their role in activating Nrf2 to enhance vascular health and antioxidant defenses[↩]
- Peluso et al., 2018 - This study explores the anti-inflammatory effects of oleocanthal, showing its ability to inhibit IL-6 and TNF-α, key cytokines involved in inflammation-related diseases[↩]
- Oliveras-López et al., 2014 - This research highlights the role of hydroxytyrosol in upregulating SOD2 and GPX1, which contribute to antioxidant protection and cellular defense mechanisms[↩]
- Swanson et al., 2012 - This study examines the effects of omega-3 fatty acids on APOA5 and FADS1 gene regulation, impacting cardiovascular and brain function[↩]
- Burdge & Calder, 2005 - A foundational study demonstrating how ALA influences PPAR-γ expression, modulating lipid metabolism and reducing inflammatory responses[↩]
- Holick, 2007 - This research provides comprehensive insights into vitamin D3's role in calcium homeostasis, immune function, and chronic disease prevention[↩]
- Lucas et al., 2011 - This study explores how oleocanthal suppresses pro-inflammatory cytokines IL-6 and TNF-α, reducing systemic inflammation and chronic disease risk[↩]
- Granados-Principal et al., 2010 - A study demonstrating hydroxytyrosol’s impact on SOD2 and GPX1 gene expression, enhancing antioxidant defenses and cellular protection[↩]
- Scotece et al., 2012 - This study explores the anti-inflammatory properties of oleocanthal, showing its ability to inhibit IL-6 and TNF-α, key mediators of chronic inflammation[↩]
- Zrelli et al., 2011 - Research demonstrating hydroxytyrosol's ability to enhance the activity of antioxidant enzymes such as SOD2 and GPX1, providing cellular protection against oxidative stress[↩]
- Giner et al., 2016 - A study highlighting how oleuropein influences NF-κB signaling pathways, playing a crucial role in immune system regulation and inflammation control[↩]
