Urolithins are gut-derived metabolites formed after consuming pomegranate ellagitannins. They play a vital role in reducing inflammation, supporting gut health, and improving cellular energy — particularly urolithin A, which is now being studied for its mitochondrial and anti-aging effects.
When ellagitannins from pomegranate are metabolized by gut bacteria into urolithins, they can:
- Promote mitophagy — the recycling of damaged mitochondria
- Support energy production and muscular endurance
- Reduce systemic inflammation and oxidative stress
- Strengthen gut barrier integrity and microbiota balance
👉 Our fermented pomegranate formula is crafted to support urolithin production naturally by enhancing gut bioavailability.
Recent research is uncovering the therapeutic power of urolithins:
- Urolithin A activates mitophagy, enhancing muscle function and energy metabolism in both preclinical and human trials 1.
- Ellagitannins from pomegranate are converted to urolithins by gut microbiota, but conversion depends on the individual’s microbial profile 2.
- Fermentation may improve the bioaccessibility of ellagitannins, enhancing urolithin formation 3.
These findings position urolithins as a next-generation target in food-based therapeutics.
Urolithins are the reason why pomegranate is more than just a fruit — it’s a biological activator. By supporting mitochondrial function, gut health, and anti-inflammatory responses, these metabolites offer truly functional benefits for long-term vitality.
⚠️ Since not everyone produces urolithins equally, choosing fermented and polyphenol-rich pomegranate products may support optimal conversion and benefit.
- Andreux, P., et al. The mitophagy activator urolithin A is safe and improves mitochondrial health in humans. Nature Communications, 2019[↩]
- Piwowarski, J.P., et al. Role of gut flora in urolithin production. Fitoterapia, 2015[↩]
- Landete, J.M., Ellagitannins, ellagic acid and their microbial metabolites. Food Research International, 2011[↩]
