Vitamin B12 and folate work closely together in essential metabolic processes. A deficiency in B12 prevents folate from being properly activated in the body, creating what’s known as a “functional folate deficiency” — even when folate intake is adequate.

When B12 is deficient, even high folate intake can’t fully support:

• DNA synthesis and healthy cell replication
• Red blood cell formation and oxygen transport
• Nervous system health and brain function
• Homocysteine metabolism and cardiovascular health

👉 Our functional formulations support both folate and B12 synergy — essential for energy, focus, and cellular balance.

Research shows that B12 deficiency can “trap” folate, making it unusable at the cellular level:

• This is known as the methyl trap hypothesis — where folate becomes metabolically unavailable without sufficient B12 ¹.
• Functional folate deficiency may mimic true folate deficiency, leading to megaloblastic anemia, neurological symptoms, and fatigue ².

This highlights the importance of monitoring and supporting both nutrients—especially in vegan or vegetarian populations.

A deficiency in B12 can quietly block folate’s activity in the body, leading to deeper imbalances. Ensuring both nutrients are present and bioavailable is key to supporting energy, cognition, and long-term cellular health.

⚠️ If you follow a vegan diet or experience signs of fatigue or anemia, speak with your healthcare provider about checking B12 and folate levels.