Vitamin B12 and folate work closely together in essential metabolic processes. A deficiency in B12 prevents folate from being properly activated in the body, creating what’s known as a “functional folate deficiency” — even when folate intake is adequate.
When B12 is deficient, even high folate intake can’t fully support:
- DNA synthesis and healthy cell replication
- Red blood cell formation and oxygen transport
- Nervous system health and brain function
- Homocysteine metabolism and cardiovascular health
👉 Our functional formulations support both folate and B12 synergy — essential for energy, focus, and cellular balance.
Research shows that B12 deficiency can “trap” folate, making it unusable at the cellular level:
- This is known as the methyl trap hypothesis — where folate becomes metabolically unavailable without sufficient B12 .
- Functional folate deficiency may mimic true folate deficiency, leading to megaloblastic anemia, neurological symptoms, and fatigue .
This highlights the importance of monitoring and supporting both nutrients—especially in vegan or vegetarian populations.
A functional folate deficiency caused by low B12 can silently impair energy, cognition, and red blood cell formation.
⚠️ If you follow a vegan diet or experience signs of fatigue or anemia, speak with your healthcare provider about checking B12 and folate levels.
