What are punicalagins? Punicalagins are large, water-soluble polyphenols found almost exclusively in pomegranate. They are the most abundant and bioactive class of ellagitannins in the fruit and are responsible for its potent antioxidant, anti-inflammatory, and mitochondrial effects ¹.

Once consumed, punicalagins are broken down in the colon by gut bacteria into urolithins — a process critical to unlocking their full health potential.

• Antioxidant defense: Punicalagins have higher antioxidant capacity than green tea or red wine polyphenols
• Mitochondrial activation: Their metabolites (urolithins) stimulate mitophagy and cellular energy
• Gut microbiome support: Serve as prebiotic-like compounds that shape a healthier microbial ecosystem

If you’re wondering what are punicalagins, they are the gateway to pomegranate’s most profound health benefits.

• Use 1 tbsp daily of fermented pomegranate concentrate to ensure high punicalagin intake
• Support your gut microbiota with fiber to enable the conversion to urolithins
• Choose whole food concentrates over extracts or juices, which may lack full ellagitannin profiles

MILESTONE® pomegranate concentrates are validated to contain >10,000 mg/kg polyphenols, with punicalagins as a dominant class ².

Punicalagins are pomegranate’s master molecules — activating gut-driven transformation and mitochondrial resilience.

Tip: Look for fermented, lab-validated pomegranate — not juice — to truly benefit from punicalagins.