At a cellular level, polyphenols interact with:
- Enzymes
- Receptors
- Transcription factors
- Immune regulators
Let’s look at just a few functions:
Olive oil is often praised for being rich in monounsaturated fats — but what truly sets it apart are its polyphenols.
Two in particular:
- Oleocanthal – a compound with strong anti-inflammatory activity, comparable in action to ibuprofen
- Hydroxytyrosol – one of the most potent natural antioxidants, shown to protect neurons, vascular endothelium, and mitochondria
But what makes these compounds so unique isn’t just their antioxidant score — it’s their cellular precision.
They:
- Inhibit COX enzymes (inflammatory signaling)
- Improve oxidative resilience in immune and neural cells
- Regulate gene pathways tied to detoxification, immunity, and metabolism
And unlike synthetic antioxidants or isolated curcumin, these polyphenols occur naturally in synergy with a fatty acid matrix, making them:
- Highly bioavailable
- Less dependent on external absorption enhancers
- Perfect for a natural olive polyphenol supplement designed to work with — not against — the body
Pomegranate isn’t just a source of vitamin C — it’s one of the richest plant sources of ellagitannins and punicalagins, two classes of polyphenols that undergo gut transformation into bioactive metabolites.
One of the most important of these?
💡 Urolithin A — a compound shown to:
- Trigger mitophagy (cellular recycling of damaged mitochondria)
- Improve muscle endurance and mitochondrial function
- Support glucose metabolism and immune regulation,
What’s critical here is the role of the gut microbiome in unlocking these benefits:
- Without proper gut flora, ellagitannins may pass through unconverted
- But in a fermented or pre-digested polyphenol supplement, you bypass that risk
- That’s exactly the design philosophy behind your natural pomegranate polyphenol supplement line — microbiome-aware, mitochondria-targeted, clinically relevant
These aren’t just fruit extracts. They are precision molecules, transformed by biology, and delivered by design.
While individual polyphenols show promising results in labs, they rarely exist in isolation in nature.
And they work best when:
- Paired with other bioactives (like D3, B12, potassium)
- Delivered within a food-based matrix (not synthetic fillers)
- Supported by fat, fermentation, or fiber to improve uptake
Clinical synergy has been shown between:
- Ellagitannins + B vitamins for mitochondrial health and red blood cell support
- Hydroxytyrosol + Omega-3s for inflammation resolution
- Oleocanthal + D3 for immune modulation and mood balance
In fact, in one study:
- A food-formulated polyphenol supplement outperformed isolated polyphenol capsules in reducing inflammation markers by over 30%
This is the secret of biofunctional design:
You don’t just deliver nutrients — you deliver them in ways the body knows how to use.
That’s the MILESTONE® difference:
Every formulation is engineered with synergy in mind — not just dosage.
Most antioxidant supplements — even premium ones — are built on simplified chemistry:
- 💊 Isolated vitamin C (ascorbic acid)
- 💊 Generic flavonoids (like quercetin or EGCG)
- 💊 Lab-synthesized compounds, often in crystalline or powdered form
These offer limited value because they:
- Operate on a single antioxidant mechanism
- Require high doses to compensate for poor bioavailability
- Often lack synergy with other nutrients or fats
Polyphenols, especially those in olive oil and pomegranate, function differently:
They signal, not just shield.
- Oleocanthal doesn’t just neutralize free radicals — it actively modulates inflammation
- Hydroxytyrosol improves mitochondrial respiration and membrane integrity
- Urolithins (from ellagitannins) trigger mitophagy — a self-cleaning function that no synthetic antioxidant can replicate
They reach deeper systems.
Polyphenols cross biological barriers (blood-brain, gut lining), interact with the microbiome, and communicate with genes, enzymes, and hormones
This is why a truly effective antioxidant strategy must go beyond defense.
It must support cellular intelligence — and that’s what polyphenols are designed to do. , ((Wang, L., et al. Free Radic Biol Med, 2014)
Not all polyphenol products are created equal.
In fact, most fall short for one of three reasons:
A true polyphenol supplement should:
- Be made from whole-food raw materials
- Retain their native bioactive structure
- Be tested for polyphenol concentration (mg/kg or mg/serving)
- Be delivered in a form the body can recognize, absorb, and use
Polyphenols are only as powerful as their delivery system — and that’s where most formulas fail.
MILESTONE® bridges this gap by combining:
- Clinical-grade olive oil
- Fermented pomegranate concentrates
- Food-matrix cofactors (D3, B12, potassium, etc.)
…to ensure every polyphenol is biologically active, not just chemically present.
Anyone can claim their product contains “plant polyphenols.”
But very few deliver them in a way that the body can truly absorb, convert, and activate.
MILESTONE® is built on food-sourced polyphenols with biological purpose, not just chemical presence.
Pomegranate Curcumin + Micellized D3
Ellagitannins from fermented pomegranate concentrate, paired with turmeric extract and advanced micellized vitamin D3 — built for mitochondrial health, mood, and inflammation support.
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Pomegranate + Vitamin B12
A microbiome-friendly, fermented polyphenol formula designed to support red blood cell production, brain function, and endurance — thanks to urolithin-generating ellagitannins.
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High Phenolic Olive Oil with Polyphenols (Omega 6-9)
One of the few globally available oils independently verified to contain over 1000 mg/kg of active polyphenols, including oleocanthal and hydroxytyrosol. Supports cognitive, metabolic, and immune health.
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These aren’t extracts. They’re clinical-grade, whole food–based tools — backed by precision sourcing and scientific logic.
